Nutrient partitioning, HISS, and a revolution in human health

In 1996, Dr. Wayne Lautt and his colleagues first discovered a hormone they called hepatic insulin-sensitizing substance (HISS).

Through their ongoing research, Dr. Lautt and his SciMar team have determined that it is important for HISS and the hormone insulin to be in healthy balance. HISS, when adequately produced, stimulates the body’s ability to partition glucose into muscle. When the liver does not adequately produce HISS, the pancreas produces additional insulin, which causes nutrient energy to be partitioned into fat.

Their work is keenly focused on this process of “Nutrient Partitioning” and on developing a series of “NuPa” products to measure metabolic health and to stimulate the production of HISS.

Science has proven so far that this essential secretion of HISS is hindered by stress, the lack of exercise, the consumption of sugar, and other lifestyle factors. Therefore, the goal of SciMar’s work is to determine ways for the body to always produce the right amount of HISS and to keep HISS and insulin in a healthy balance. The science suggests that when the right amount of HISS is present, nutrient partitioning is in balance, thereby helping people to avoid type 2 diabetes. For those already living with type 2 diabetes, managing HISS effectively is expected to help people avoid the disease’s worst impacts.

Changing the focus to HISS and nutrient partitioning will change the prevention and treatment paradigms in diabetes.

The Research

Dr. Lautt, Professor Emeritus at the Department of Pharmacology and Therapeutics at the University of Manitoba, has about 220 peer-reviewed publications to his credit. Of these, over 60 are related to HISS, including the following:

  1. Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting
  2. Meal-induced Insulin Sensitization in Conscious and Anesthetized Rat Models Comparing Liquid Mixed Meal with Glucose and Sucrose
  3. Synergistic Protection by S-adenosylmethionine with Vitamins C and E on Liver Injury Induced by Thioacetamide in Rats
  4. HISS-dependent Insulin Resistance (HDIR) in Aged Rats is Associated with Adiposity, Progresses to Syndrome X, and is Attenuated by a Unique Antioxidant Cocktail
  5. Meal-induced Insulin Sensitization (MIS) and its Parasympathetic Regulation in Humans
  6. Bethanechol and N-acetylcysteine Mimic Feeding Signals and Reverse Insulin Resistance in Fasted and Sucrose-induced Diabetic Rats
  7. Absence of meal-induced insulin sensitization (AMIS) in aging rats is associated with cardiac dysfunction that is protected by antioxidants
  8. Lifestyle Impact on Meal-induced Insulin Sensitization in Health and Prediabetes: a Focus on diet, antioxidants, and Exercise Interventions
  9. Obesity as an Early Symptom of the AMIS Syndrome